5-MeO-DMT

"5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent, short-acting psychedelic compound found in several South American plant species (Furst, 1976). Historical use of 5-MeO-DMT-containing plants, including Anadenanthera peregrina and Virola theiodora, in psychoactive snuff preparations is well documented among Indigenous peoples of the Caribbean and South America, including the Taíno, Yanomami, and Tukano (Guss, 1986, Schultes, 1979, Torres and Repke, 2006). These snuff preparations, known as cohoba, vilca, yopo, or epéna, depending on plant source and region, are typically insufflated (administered intranasally) using long bamboo or hollow bird bones and Y-shaped nasal applicators (Safford, 1916, Schultes, 1976, Torres and Repke, 2006)."

Source

A.M. Ortiz Bernal, C.L. Raison, A.M. Vargas Prieto, A.K. Davis, Fabricated ancestrality: The Sonoran Desert toad, psychedelic globalization, and the ecological politics of 5-MeO-DMT, Psychedelics, Volume 3, 2026, 100012, ISSN 2950-4848, doi.org/10.1016/j.psyche.2026.100012.