DEA Announces Its Intent to Place 7-OH and Three Related Substances Temporarily Into Schedule One
On July 6, 2026, the Drug Enforcement published a notice of its intent to place 7-Hydroxymitragynine and three related substances temporarily into Schedule One of the Controlled Substances Act.
According to the Congressional Research Service's report "Temporary Control of 7-Hydroxymitragynine (7-OH) and Related Substances Under the Controlled Substances Act" (LSB11457):
"On July 1, 2026, DEA issued a new notice of its intent to temporarily control 7-OH in Schedule I. Specifically, the notice states the intent to schedule substances that contain a concentration of '7-[OH] above a specified threshold, including its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers.' The threshold is to be set at 0.05% 7-OH for the kratom plant. For articles produced synthetically or derived from the kratom plant 'and further processed to manufacture alternative dosage forms such as extracts, concentrates, processed edibles, or pressed pills,' the threshold is set to be either 0.05% 7-OH or 1 milligram of 7-OH in the article.
"In a separate notice, DEA announced its intent to temporarily place in Schedule I three 7-OH-related substances known as mitragynine pseudoindoxyl (MP), dihydro-7-hydroxymitragynine (MGM-15), and 9-fluoro-dihydro-7-hydroxymitragynine (MGM-16), 'including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers.' The notice states that MP is a "chemical rearrangement product" of 7-OH, MGM-15 is 'derivative of 7-OH,' and MGM-16 is a 'highly potent opioid and shares a similar pharmacological profile with [MP] and MGM-15.' It further states that all three compounds are 'potent opioids that share a similar pharmacological profile with 7-[OH]" and "produce analgesic effects that [are] more potent than morphine.' The notice indicates that MP and MGM-15 are currently available in the consumer marketplace. While DEA has not found evidence of consumer sales of MGM-16, it has identified a vendor site listing it for future sale, and thus concludes that 'to schedule MGM-15 without MGM-16 would create a regulatory loophole that manufacturers are already poised to exploit.' The temporary scheduling of MP, MGM-15, and MGM-16 will not be limited to substances containing threshold amounts of the compounds.
"The two notices of intent were published in the Federal Register on July 6, 2026. Each notice stated that a temporary scheduling order would be published in the Federal Register on or after August 5, 2026, would take effect on the date published, and would remain in effect for two years, subject to a possible one-year extension if permanent scheduling proceedings are pending. If the temporary scheduling orders are issued and take effect as planned, 7-OH above the specified threshold, MP, MGM-15, and MGM-16 would be legally treated as Schedule I controlled substances for the duration of the temporary scheduling. They would thus be subject to the applicable regulatory and criminal trafficking provisions of the CSA, and handling these substances outside the context of federally approved research studies would be a federal crime."