(Cannabinoids and Skin Cancer) "The present data indicate that local cannabinoid administration may constitute an alternative therapeutic approach for the treatment of nonmelanoma skin cancer. Of further therapeutic interest, we show that skin cells express functional CB2 receptors. The synergy between CB1 and CB2 receptors in eliciting skin tumor cell apoptosis reported here is nonetheless intriguing because it is not observed in the case of cannabinoid-induced glioma cell apoptosis (21, 22). In any event, the present report, together with the implication of CB2- or CB2-like receptors in the control of peripheral pain (40–42) and inflammation (41), opens the attractive possibility of finding cannabinoidbased therapeutic strategies for diseases of the skin and other tissues devoid of nondesired CB1-mediated psychotropic side effects."
Casanova, M. Llanos; Blázquez,Cristina; Martínez-Palacio, Jesús; Villanueva, Concepción; Fernández-Aceñero, Jesús; Huffman, John W.; Jorcano, José L.; and Guzmán, Manuel, "Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors," Journal of Clinical Investigation (Ann Arbor, MI: American Society for Clinical Investigation, January 2003), p. 49.
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