In 2019, among people aged 12 and older in the United States:
An estimated 35,803,000 people were past-month users of any illicit drug.
An estimated 31,606,000 people were past-month users of marijuana or hashish.
An estimated 3,101,000 people were past-month users any opioid (including heroin and prescription pain relievers).
An estimated 1,998,000 people were past-month users of cocaine.
An estimated 58,074,000 people were past-month users of tobacco products.
An estimated 139,727,000 people were past-month alcohol users, of whom 65,845,000 were "binge drinkers" (binge drinking is defined as five or more drinks (for males) or four or more drinks (for females) on the same occasion on at least one day in the past 30 days), of whom 16,044,000 were "heavy" alcohol users (heavy alcohol use is defined as binge drinking on the same occasion on each of five or more days in the past 30 days).

Table: Estimated Prevalence of Past-Month Substance Use in US by Those Aged 12 and Older (Numbers In Thousands)