Medical Marijuana - Research - 12-22-10

Cannabis and Diabetes

(Cannabinoids and Diabetic Cardiomyopathy) "Remarkably, CBD [Cannabidiol] attenuated myocardial dysfunction, cardiac fibrosis, oxidative/nitrative stress, inflammation, cell death, and interrelated signaling pathways. Furthermore, CBD also attenuated the high glucose-induced increased reactive oxygen species generation, nuclear factor-B activation, and cell death in primary human cardiomyocytes.
"Conclusions: Collectively, these results coupled with the excellent safety and tolerability profile of CBD in humans, strongly suggest that it may have great therapeutic potential in the treatment of diabetic complications, and perhaps other cardiovascular disorders, by attenuating oxidative/nitrative stress, inflammation, cell death and fibrosis."


Rajesh, Mohanraj; Mukhopadhyay,Partha; Batkai, Sandor; Patel, Vivek; Patel, Keita; Matsumoto, Shingo; Kashiwaya, Yoshihiro; Horvath, Béla; Mukhopadhyay, Bani; Becker, Lauren; Hasko, György; Liaudet, Lucas; Wink, David A.; Veves, Aristidis; Mechoulam, Raphael; Pacher, Pal, "Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy," Journal of the American College of Cardiology (San Diego, CA: American College of Cardiology Foundation: December 2010) Vol. 56, No. 25, p. 2115.